Programs failing to quit & system to shut down

My Mac has been slowing down, with programs (especially Photoshop, Firefox) failing to close down and sometimes the system fails to shut down, I just get coloured spinning wheel forever. Also Time Machine fails to find the backup disk even though it is on the desktop. After failing to shut down the computer takes an age to start up and I have to turn the backup disk off and on as the icon has disappeared.
I noticed high cpu usage from mds and mdworker so I've reindexed Spotlight via Terminal and waiting to see if this helps. I also ran Etrecheck and there seems to be stuff there that needs sorting, hoping someone can help me interpret it.
EtreCheck version: 2.1.5 (108)
Report generated 2 January 2015 23:30:07 GMT
Click the [Support] links for help with non-Apple products.
Click the [Details] links for more information about that line.
Click the [Adware] links for help removing adware.
Hardware Information: ℹ️
    Mac Pro (Mid 2010) (Verified)
    Mac Pro - model: MacPro5,1
    1 2.8 GHz Quad-Core Intel Xeon CPU: 4-core
    4 GB RAM
        DIMM 1
            1 GB DDR3 ECC 1066 MHz ok
        DIMM 2
            1 GB DDR3 ECC 1066 MHz ok
        DIMM 3
            1 GB DDR3 ECC 1066 MHz ok
        DIMM 4
            1 GB DDR3 ECC 1066 MHz ok
    Bluetooth: Old - Handoff/Airdrop2 not supported
    Wireless:  en2: 802.11 a/b/g/n
Video Information: ℹ️
    ATI Radeon HD 5770 - VRAM: 1024 MB
        SyncMaster 1680 x 1050 @ 60 Hz
        spdisplays_display_connector
        spdisplays_display_connector
System Software: ℹ️
    Mac OS X 10.6.8 (10K549) - Uptime: 7:46:26
Disk Information: ℹ️
    HL-DT-ST DVD-RW GH61N
    WDC WD1001FALS-41Y6A0 disk0 : (931.51 GB)
        - (disk0s1) <not mounted> : 210 MB
        Macintosh HD (disk0s2) / : 782.76 GB (509.45 GB free)
        BOOTCAMP (disk0s3) /Volumes/BOOTCAMP : 217.10 GB (177.60 GB free)
USB Information: ℹ️
    Lexmark International Lexmark C544
    Apple, Inc. Keyboard Hub
        Apple Inc. Apple Keyboard
    Griffin Technology, Inc iMic USB audio system
    Apple Inc. BRCM2046 Hub
        Apple Inc. Bluetooth USB Host Controller
Firewire Information: ℹ️
    Formac Elektronik GmbH Formac Disk Maxi 800mbit - 800mbit max
        - (disk1s1) <not mounted> : 210 MB
        Time Machine FW (disk1s2) /Volumes/Time Machine FW : 749.81 GB (60.62 GB free)
Kernel Extensions: ℹ️
        /Applications/Transmit.app
    [not loaded]    com.panic.TransmitDisk.transmitdiskfs (4.0.0 - SDK 10.6) [Support]
        /Library/Application Support/Roxio
    [not loaded]    com.roxio.TDIXController (1.1) [Support]
        /System/Library/Extensions
    [loaded]    com.sophos.kext.sav (9.2.0 - SDK 10.8) [Support]
    [loaded]    com.sophos.nke.swi (9.2.0 - SDK 10.8) [Support]
Startup Items: ℹ️
    ColdFusion8: Path: /Library/StartupItems/ColdFusion8
    MySQLCOM: Path: /Library/StartupItems/MySQLCOM
    Startup items are obsolete in OS X Yosemite
Problem System Launch Daemons: ℹ️
    [not loaded]    org.samba.winbindd.plist [Support]
Launch Agents: ℹ️
    [not loaded]    com.adobe.AAM.Updater-1.0.plist [Support]
    [loaded]    com.adobe.CS4ServiceManager.plist [Support]
    [loaded]    com.adobe.CS5ServiceManager.plist [Support]
    [running]    com.sophos.uiserver.plist [Support]
Launch Daemons: ℹ️
    [loaded]    com.adobe.fpsaud.plist [Support]
    [invalid?]    com.adobe.SwitchBoard.plist [Support]
    [loaded]    com.adobe.versioncueCS4.plist [Support]
    [loaded]    com.barebones.authd.plist [Support]
    [running]    com.sophos.common.servicemanager.plist [Support]
User Launch Agents: ℹ️
    [loaded]    com.adobe.AAM.Updater-1.0.plist [Support]
    [loaded]    com.adobe.ARM.[...].plist [Support]
    [loaded]    com.google.keystone.agent.plist [Support]
    [loaded]    com.macpaw.CleanMyMac.helperTool.plist [Support]
    [loaded]    com.macpaw.CleanMyMac.trashSizeWatcher.plist [Support]
    [loaded]    com.macpaw.CleanMyMac.volumeWatcher.plist [Support]
User Login Items: ℹ️
    Suitcase Fusion 3    Application (/Applications/Suitcase Fusion 3.app)
Internet Plug-ins: ℹ️
    JavaAppletPlugin: Version: 13.9.8 - SDK 10.6 Check version
    FlashPlayer-10.6: Version: 16.0.0.235 - SDK 10.6 [Support]
    QuickTime Plugin: Version: 7.6.6
    Flash Player: Version: 16.0.0.235 - SDK 10.6 [Support]
    AdobePDFViewer: Version: 9.5.5 [Support]
    OfficeLiveBrowserPlugin: Version: 12.3.6 [Support]
    iPhotoPhotocast: Version: 7.0 - SDK 10.7
Audio Plug-ins: ℹ️
    iSightAudio: Version: 7.6.6
3rd Party Preference Panes: ℹ️
    Adobe Version Cue CS4  [Support]
    Flash Player  [Support]
    MacFUSE  [Support]
    MySQL  [Support]
Time Machine: ℹ️
    Time Machine information requires OS X 10.7 "Lion" or later.
Top Processes by CPU: ℹ️
         3%    mds
         2%    activitymonitord
         2%    mdworker32
         1%    firefox
         1%    WindowServer
Top Processes by Memory: ℹ️
    597 MB    firefox
    292 MB    InterCheck
    289 MB    mds
    180 MB    SophosScanD
    146 MB    SophosAntiVirus
Virtual Memory Information: ℹ️
    171 MB    Free RAM
    2.20 GB    Active RAM
    1.40 GB    Inactive RAM
    520 MB    Wired RAM
    64.90 GB    Page-ins
    633 MB    Page-outs
Diagnostics Information: ℹ️
    Jan 2, 2015, 03:44:16 PM    Self test - passed
    Dec 31, 2014, 03:19:43 PM    /Users/[redacted]/Library/Logs/DiagnosticReports/Adobe Photoshop CS5_2014-12-31-151943_[redacted].crash

Un-install Sophos and CleanMyMac. Neither are needed.
You do not need to use cleaning programs. They can destroy your computer operation as they may already have done.
CleanMyMac - Uninstall
CleanMyMac2 Un-install
After un-installing, run this program to make sure you got all the pieces.
EasyFind – Spotlight Replacement
Sophos Un-install
Activity Monitor – Monitor Performance Problems  
Performance Guide
Why is my computer slow
Why your Mac runs slower than it should
Things you can do to resolve slowdowns  see post by Kappy

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