PS CS4 could not save because the file is locked

I saw this post, my problem is very similar, but this solution does not solve my problem:
http://forums.adobe.com/message/2121454#2121454
Everytime I try to save a photoshop file I get the "Could not save becasue this file is locked" -- and then I go to save again and it does save, becasue the file has disappeared from where I had originally saved it!
This is VERY irritating, as it is not happening EVERY time I try to save a photoshop file.
In reference to the previous post about this, I do not use Spotlight, and often I do not have anything else open when working on these photoshop files.
I am using CS4, and this occurs when saving files both on and off a server.
I am afraid I will at some point end up losing a file.
Any suggestions?

No anti-virus software (they cause far more problems than they solve, at least on a semi-secure network), I don't leave Bridge running. iTunes is running, so is InerTrak (time tracking software)... so it has to be Spotlight or Time Machine unless Activity Monitor will lock files. Or it could be Quicksilver, which creates indices like Spotlight.
First thing I'm doing is adding all my hard drives to "Prevent Spotlight from searching these locations" and we'll see if this comes up again.
Could it be the Finder? Does the Finder lock the file while reading the thumbnail?
I'm surprised that there's no way to tell what process has locked the file.
OK, last bit: Why doesn't Photoshop lock the file when it's open so that other programs won't open it?

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