PS CS6 (MAC) Can't open scratch file - locked

This is new behavior as I've used PS before on this computer and can't remember anything as having changed (ie. OS or new apps/settings). I get the "could not open scratch file because it is locked or you don't have permission" message and then PS quits.
I've tried uninstalling and reinstalling. I've tried deleting the settings file.
I'm using a MacBook Pro running os 10.7.5.

Have you tried to reset preferences?  Start PS and immediately hold down shift cmd option keys.  Should get a reset window.

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