PSCS4 could not save because the file is locked or was left open

Hello—
I'm getting this error a lot, maybe once out of every dozen attempts to save. This occurs on files that are indeed open... because I've opened them in Photoshop! I open the file, make a change, hit CMD-S and get this message.
The finder's info panel says that I have permission to read and write the file.
This happens with multiple file types, not just one file.
All my work is done locally. Not trying to load or save across a network or any such.
Any guesses what might be going on? Obviously it's easy to work around. I "Save As" and give it a new name, then later delete the old file and rename the new one. Still, it's annoying, especially after waiting 10 minutes for a save to complete on a large file, then having to start over.
Thanks in advance!
Steve

No anti-virus software (they cause far more problems than they solve, at least on a semi-secure network), I don't leave Bridge running. iTunes is running, so is InerTrak (time tracking software)... so it has to be Spotlight or Time Machine unless Activity Monitor will lock files. Or it could be Quicksilver, which creates indices like Spotlight.
First thing I'm doing is adding all my hard drives to "Prevent Spotlight from searching these locations" and we'll see if this comes up again.
Could it be the Finder? Does the Finder lock the file while reading the thumbnail?
I'm surprised that there's no way to tell what process has locked the file.
OK, last bit: Why doesn't Photoshop lock the file when it's open so that other programs won't open it?

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