Publication Help - PLEASE

Question

I have 19 reports that get sent to approx 186 different email addresses, each report can go to multiple emails and each email address can receive multiple reports. End result is approximately 7400 monthly instances and 12000 weekly instances.
Most of the reports have parameters, some static, some dynamic, some have none. Of the reports that are dynamic.... the prompt for clientclass is on almost all of the reports asking for prompts.
I have created a dynamic recipient universe/webi report that has the recipient email address as they are all external contacts and not set up in BO. This includes facility code, facility name, recipient name & recipient email.
I am getting ready to create a publication and here is my question.... is the best way to go at this at the report or email address level... meaning... should i create a publication for each report with a profile for the dynamic recipients or for each email recipeint???
Also... does timeframe matter, some are monthly some are weekly, can that be handled in one publication, also some pdf, some excel???
For example... I have
1 report for 32 facilities goes to 45 different emails can be either monthly or weekly
1 report for 63 facilities goes to 88 different emails can be either monthly or weekly
OR
1 person gets 3 reports for 9 different facilities can be either monthly or weekly
etc....
Just trying to figure out the most efficient way of setting this up as I have been in the XI closet for years now.
I know this is probably pretty basic but I am at a pretty archaic company with little change over the years and we are just now attempting to upgrade all our systems to 3.1.
Any and all help is greatly appreciated.

Answer 1

Thanks Tracy - I was able to delete the subscription on the publication server and was able to recreate most of the subscription on the subscription server but so far have been unable to start the subscription agent. 
I ran the command exec sp_link_publication yesterday and received the error: "The Microsoft Distributed Transaction Coordinator (MS DTC) service could not be contacted. If you would like distributed transaction functionality, please start this service." 
WTF? Anyhow - Googled this issue for awhile and was advised to run a command with a utility called subinacl.exe but the command failed stating that access is denied even though i'm an admin on my computer & I ran the command promp with elevated privileges. 
I also downloaded a tool called DTCping.exe and was able to dtcping each server when the utility was running on the publication & subscription servers after tweaking some registry settings on the subscription server & restarting. 
Well now i'm still stuck because the subscription agent is failing to start stating (this is the last error in the job that kicks off the agent): 
Agent message code 21056. The subscription to publication 'publish_igt_period_data' has expired or does not exist.
Whew! Well i have other priorities this morning but will update this thread if I make any progress on this issue later... 
Carl