Publishing topology causes high CPU times? What?

I have a mixed environment currently with 2 lync 2010 front ends (Production) and 4 lync 2013 front ends (pilot pools).
When I make a change and publish the topology all 6 2010 and 2013 front ends go to 100% CPU time.  IIS Worker Process is to blame and issuing "iisreset" on each server fixes it.
Where do I ever begin to diagnose this? No odd network traffic in packet captures, but I know right away when it happens as SCOM starts blowing up on CPU time and Lync conference join errors.

Each 60 seconds a task is run to determine if a change has been made to the CMS master and needs to be replicated. If a change was made, all replica need to synchronize with the CMS master. The replication may cause the high CPU usage. You should check the
duration of the High CPU usage. I think once the replication completes, the CPU usage will go down.
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