Qosmio F30 - Missing or corrupt file

Please can anybody help.
Have a Toshiba Qosmio F30-117 suddenly stopped working message in safe mode it suggests following file missing or corrupt Windows\sytem32\config\system.
Screen consists of thick blue & black lines with the windows logon showing.
Then allows you to only start in safe mode gives above reading and goes off also suggests windows not fully loaded have tried to reload but not possible. I know its old but its my friend any suggestions have had people look at it 30 here 30 there but no solutions only that it might be hard drive take it away and do it 150 but it might not work.
I am of old average inteligence could i fix it by replaceing suggested parts any help please or suggestions thanks for reading John.

Hello
What OS is installed at the moment?
If Windows doesnt start anymore there is not much what you can do and I would recommend reinstalling Windows from Toshiba recovery disk. Such a new and clean installation can help to get Windows working and new installed Windows system will also run a little bit faster and more stable so its recommendable to reinstall it from time to time (1-2 years).
So take the Toshiba recovery disk and follow the screen instructions to reinstall Windows.

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Toshiba NB200-11L
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