QuarkXpress 8 won't start up and the filesystem verify failed

HELP Quark won't start - Exception Type: EXCBADACCESS (SIGBUS)
Exception Codes: KERNPROTECTIONFAILURE at 0x0000000000000004
Then the filesystem verify failed -
Verifying volume “Macintosh HD”
Performing live verification.
Checking Journaled HFS Plus volume.
Checking Extents Overflow file.
Checking Catalog file.
Checking multi-linked files.
Checking Catalog hierarchy.
Checking Extended Attributes file.
Checking volume bitmap.
Checking volume information.
Invalid volume file count_
(It should be 464046 instead of 464060)
Invalid volume directory count_
(It should be 118092 instead of 118078)
The volume Macintosh HD needs to be repaired.
Checking multi-linked files.
Checking Catalog hierarchy.
Checking Extended Attributes file.
Checking volume bitmap.
Checking volume information.
Invalid volume file count_
(It should be 464046 instead of 464060)
Invalid volume directory count_
(It should be 118092 instead of 118078)
Error: Filesystem verify or repair failed.

Safe boot runs fsck as part of the process, which is one of the reasons it takes a little longer. The Unix fsck routine is essentially the disk repair routine that Disk Utility runs and if it fixed the disc directory errors, then good.
Is Quark crashing on open or are you getting a kernel panic? It looks like you have some excerpts from the crash log in your original post, so I am guessing crash on open. There may be a damaged file in the Quark world or more likely a corrupt cache file somewhere.
You might look in /Users/yourshort_username/Library/Caches to see if there is a Quark cache folder and just trash it and try again for a start.
If that doesn't work, then you might try Applejack at http://sourceforge.net/projects/applejack/ and let it clean out things a little more thoroughly.

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