Raid0 on usb 3.0 drives

Hello,
I am currently running a Linux box with 16x 2TB in a RAID6. My Mac mini server accesses the files via AFP on a 1GigE connection. I am thinking to stick all my drives into 2 MediaSonic ProRaid 8bay and configure each set as a RAID5. But I still want to consilidate all my storage. So, I was thinking to run a software RAID0 on top of the 2 8bay USB devices using OSX's Disk Utility.
Question is, should I expect any problems, since I am running a RAID on 2 USB devices? Needlesly to say, I don't want to loose my data. Has anyone ever done this?
Thanks!

I understand that USB devices do not work in the USB 2.0 ports.
What happens when USB devices are used in the 2.0 ports?  Does Windows behave as if it has detected them or does it give an error message?
Do devices work in the 2.0 ports without going through the USB hub?
Is the HUB working off USB  power or does it have a dedicated power adapter?
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