Random Artifact and "Could not save (file name) because the file is already in use or left open."

Hi,
I've been working on a collage for school, and I 'merged all layers below into one layer', and photoshop left me a random artifact on all my masks. Also, the same file has been suffering the 'Could not save...' problem. I have taken older versions of the file, brought them back to where I had been, and then a similar artifact appears (from various actions). Once the artifact appears, I can undo the action but not the artifact, and the file is useless. It happen on a second file, but the artifact was different (a rectangular hole in the middle of the masks).
I have a MBP/4GB/MacOSX 10.6.4, everything is up to date.
If anyone has any suggestions, it would be really appreciated... I'm working for a deadline at school.
Thanks,
Patrick

Hi Chris,
I have updated both the Adobe suite and the MacOSX. My school has CS5. The holes cut into the image in a geometric pattern (the rectangles) are the random artifact (cropped below).
Also, I understand 'Could not save...' means it could not save... Why it cannot save seems to be the issue. I believe you understand the circumstances of the 'Could not save...' issue, and it isn't simply that another program has it open.
http://forums.adobe.com/thread/370206?start=50&tstart=0
I don't really know if it's Adobe, Apple, or Windows issue, and I don't think it really matters. It is a problem in Photoshop, which would make it an Adobe problem... and waiting for a fix doesn't seem to be a satisfactory answer.
I don't want to make this tread about politics, I want to fix my file, and I thought it might be another symptom to a bigger problem.
Thanks for your response,
Patrick

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