Random "Lightroom encountered an error when reading from its preview cache" message

I am getting this error randomly.  When I restart LR everything is fine, until I get this error again.  This problem has recently started occurring frequently when I exit LR during the backup.  Sometimes it occurs when LR is just sitting there and I ma not interacting with it.  I have not seen a pattern as to when I get the error.
My system drive is a SSD with the LR catalog and preview cache are on another SSD used exclusively for LR.  My main data drive is RAID 0 with images and catalog backup to a NAS.  I'm running LR 5.5 64-bit on Windows 7.
I've tried deleting and rebuilding the cache which takes a while at I have 42,000 images consuming almost 6 Tb but this does not seem to have any effect.
While this is not a show stopped, it is annoying as every time the problem occurs I need to exit LR and restart.
Any help will be appreciated.

Could be the Previews.lrdata file which stores the previews? How about moving it out of it's existing location and see if you still get the error.

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