Random mail delivery delays - stuck in queue for extended periods of time

I'm really hoping someone can help me out here. I'm setting up a new OS X Mail server (upgrading from Tenon Post.Office). I'm using accounts from Active Directory and everything seems to be working great... except (you knew there was an 'except' didn't ya?) that I'm randomly getting long delays in email delivery.
From what troubleshooting I've done so far, basically the emails are coming to our domain, hitting our Symantec anti-virus / anti-spam server and then getting forwarded to my mail server fine. I can look in the SMTP logs and see the emails showing up...
But then, completely randomly, there is sometimes a long 1-6 hour delay before it transfers from the SMTP to actually being able to get the email in our clients. I can see these emails sitting in the queue, but clicking the 'Retry' and entering some of the commands I've seen on this board don't seem able to kick the queue into gear.
We're just in testing right now, so only have about 6 users on this machine, but there is going to be about 1000 when I'm all said and done, so the fact that I'm getting these delays already concerns me. Network and CPU activity are barely even showing (this is a quad Xeon server, so lots of power), so I don't think things are being overloaded, which makes me suspect some kind of configuration error.
Looking at other requests, I'm assuming I'm going to be asked for postconf -n and the output of some of the logs, so let me add that now:
The results of postconf -n
alias_maps = hash:/etc/aliases
command_directory = /usr/sbin
config_directory = /etc/postfix
daemon_directory = /usr/libexec/postfix
debugpeerlevel = 2
enableserveroptions = yes
html_directory = no
inet_interfaces = all
mail_owner = postfix
mailboxsizelimit = 0
mailbox_transport = cyrus
mailq_path = /usr/bin/mailq
manpage_directory = /usr/share/man
messagesizelimit = 41943040
mydestination = $myhostname,localhost.$mydomain,localhost,prn.bc.ca,mail.sd60.prn.bc.ca,mail.pr n.bc.ca
mydomain = prn.bc.ca
mydomain_fallback = localhost
myhostname = mail.prn.bc.ca
mynetworks = 127.0.0.1/32,142.27.0.0/16
mynetworks_style = host
newaliases_path = /usr/bin/newaliases
ownerrequestspecial = no
queue_directory = /private/var/spool/postfix
readme_directory = /usr/share/doc/postfix
recipient_delimiter = +
relayhost =
sample_directory = /usr/share/doc/postfix/examples
sendmail_path = /usr/sbin/sendmail
setgid_group = postdrop
smtpdpw_server_securityoptions = plain,login,cram-md5,gssapi
smtpdrecipientrestrictions = permitsasl_authenticated,permit_mynetworks,reject_unauthdestination,permit
smtpdsasl_authenable = yes
smtpdtlsCAfile =
smtpdtls_certfile = /etc/certificates/mail.prn.bc.ca.crt
smtpdtls_keyfile = /etc/certificates/mail.prn.bc.ca.key
smtpduse_pwserver = yes
smtpdusetls = yes
unknownlocal_recipient_rejectcode = 550
The SMTP Log
(I've bolded an email received at 13:50 as that is currently one of the emails in the queue, and it is addressed to me. It is now 14:36, so it's been in the queue for 45 minutes now).
May 23 13:17:16 mail postfix/smtpd[1153]: disconnect from unknown[142.27.144.50]
May 23 13:20:31 mail postfix/smtpd[1171]: connect from unknown[142.27.144.50]
May 23 13:20:31 mail postfix/smtpd[1171]: E670A5E12E: client=unknown[142.27.144.50]
May 23 13:20:31 mail postfix/cleanup[1172]: E670A5E12E: message-id=<[email protected]>
May 23 13:20:31 mail postfix/qmgr[2532]: E670A5E12E: from=<[email protected]>, size=8890, nrcpt=1 (queue active)
May 23 13:20:31 mail postfix/smtpd[1171]: disconnect from unknown[142.27.144.50]
May 23 13:35:49 mail postfix/smtpd[1240]: connect from unknown[142.27.144.50]
May 23 13:35:49 mail postfix/smtpd[1240]: 69A2D5E12F: client=unknown[142.27.144.50]
May 23 13:35:49 mail postfix/cleanup[1243]: 69A2D5E12F: message-id=<[email protected]>
May 23 13:35:49 mail postfix/qmgr[2532]: 69A2D5E12F: from=<CNETNetworks#[email protected]>, size=18494, nrcpt=1 (queue active)
May 23 13:35:49 mail postfix/smtpd[1240]: disconnect from unknown[142.27.144.50]
May 23 13:48:21 mail postfix/smtpd[1299]: connect from unknown[142.27.144.50]
May 23 13:48:21 mail postfix/smtpd[1299]: 2644A5E130: client=unknown[142.27.144.50]
May 23 13:48:21 mail postfix/cleanup[1302]: 2644A5E130: message-id=<[email protected]>
May 23 13:48:21 mail postfix/qmgr[2532]: 2644A5E130: from=<[email protected]>, size=2438, nrcpt=1 (queue active)
May 23 13:48:21 mail postfix/smtpd[1299]: disconnect from unknown[142.27.144.50]
May 23 13:50:30 mail postfix/smtpd[1315]: connect from unknown[142.27.144.50]
May 23 13:50:30 mail postfix/smtpd[1315]: 91EE25E131: client=unknown[142.27.144.50]
May 23 13:50:30 mail postfix/cleanup[1316]: 91EE25E131: message-id=<[email protected]>
May 23 13:50:30 mail postfix/qmgr[2532]: 91EE25E131: from=<[email protected]>, size=1966, nrcpt=1 (queue active)
May 23 13:50:30 mail postfix/smtpd[1315]: disconnect from unknown[142.27.144.50]
May 23 13:57:09 mail postfix/smtpd[1343]: connect from unknown[142.27.144.50]
May 23 13:57:09 mail postfix/smtpd[1343]: 60FF95E132: client=unknown[142.27.144.50]
May 23 13:57:09 mail postfix/cleanup[1346]: 60FF95E132: message-id=<[email protected]@SMS>
May 23 13:57:09 mail postfix/qmgr[2532]: 60FF95E132: from=<[email protected]>, size=1017, nrcpt=1 (queue active)
May 23 13:57:09 mail postfix/smtpd[1343]: disconnect from unknown[142.27.144.50]
The email access log has already scrolled farther than the emails in my list, so I won't include that unless asked.
Thanks in advance for any help offered.
Jeff
Intel X-Serve, X-Serve RAID, all kinds of other goodies Mac OS X (10.4.9) Support about 2000 Macs

A wealth of information on configuring/troubleshooting your email server can be found at:
http://osx.topicdesk.com/
I know your issues isn't particularly with SPAM, however I would try to following this tutorial on "Frontline SPAM Defense":
http://osx.topicdesk.com/content/view/38/62/
This fixed many of my email server issues. I would try this first.

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