Random users getting very slow response when opening messages/attachments or sending email

I have a small number of users, mostly very senior management of course, who are experiencing slow response when trying to open email messages and attachments or send messages.
They see the spinning wheel and sit there until it decides to open or send. If the message is opened and closed again you would expect it to be quick reopening the same message, no, it does the same thing again.
These users are all using Outlook 2010 and their mail accounts are on Exchange 2013. It does not seem to make a difference if they use a physical machine or log into a VDI.
I do not have the same issue generally, though I have experienced this when using VDI and this has been seen using a number of different machine pools so it is not a specific pool.
This is not specifically a VDI issue, as the 3rd paragraph says, the issues are seen on both physical and virtual machines.
none of the mailboxes are particularly large, most are at around 60% of quota limit, and the same limit applies to almost all mailboxes across the organization. They also do not appear to have a huge number of messages stored, other users without issues
have larger mailboxes and higher item counts. Any ideas what I need to look at to address this?

Hi,
How about OWA?
If OWA works well, it seems an issue on the Outlook client side.
Please try to run Outlook under safe mode and re-create profile for testing.
Any related error/warning/information message left in App Log?
Also consider the network Bandwidth.
Thanks
If you have feedback for TechNet Subscriber Support, contact
[email protected]
Mavis Huang
TechNet Community Support

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======= POSTED to Application Server - General forum ============
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