Reader 10.1 "Failed to load an application resource"

Hi
I upgraded from Reader X (10) to 10.1. Since then every time I start it, whether as a standalone or plug-in, I get one or more instances of an error message which says "There was an error during initialization. Failed to load an application resource (internal error)." I also note that there is no plug-ins menu.
This is getting annoying, to say the least. I am running Windows Vista SP2. Googling produced nothing relevant.
Does anyone have any ideas?
Thanks
Luke

Thanks.
Both. In Vista Add/Remove Programs gives a "Change" rather than a repair option but it runs the repair either way, says everything is ok, but it isn't.
Screenshots below
Luke

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