Reader 10 - PDF will not open in IE

I installed Reader X on a laptop at work with Win XP Pro. No problems; everything worked. I can read PDFs in IE.
I also installed Reader X on a desktop at home running Vista business. Reader X, itself, seems to work fine. I can open a PDF in Firefox which is installed on this computer. I cannot open a PDF in IE. It only wants me to download the pdf file. It doesn't open it in a window. Display PDF in Browser is checked in Internet Preferences/Web Browser Options. Manage Add-ons in IE shows both Adobe PDF Link Helper and Adobe PDF Reader add-ons as Enabled.
Does anyone have any idea what i can do to get this problem solved?
irablum1

Some times the PDF is linked to a site that is NOT on the site your visiting. If this is the case, then BOTH web sites will have to be added to the Trusted Sites.
Did you try the second step?
The other fix I have found is to Uninstall Adobe Reader, Adobe Acrobat, Adobe Flash and IE8. Install CCleaner and run the program using the default settings. This removes any old registry connections for Adobe. Then reinstall IE8 and Adobe Acrobat or Reader. Then open Adobe to make sure that the Open PDF in Web Browser is unchecked. Then Install Flash. Then go to the website to open a PDF. The PDF should now open with Adobe.
See if you can open a PDF from a different website or sites.
If your on a network, and are using ISA make sure that ISA is not blocking the PDF's ie: add these sites to the trusted list in ISA.

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