Reader dos not respond after update installation

My system is Win7 and yesterday after installation of an update for my Reader 10.0 version the program does not respond. I tried to uninstall and reinstall it many times but the result is always the same: when I double click onto the Reader symbole, the icon appears for 5 seconds trying to load the program and then disappears.
How to proceed?

Two more things to try...
Can you open Adobe Reader by itself? If so, try disabling Protected Mode [Edit | Preferences | Security (Enhanced)].
It could even be a malware issue; see http://helpx.adobe.com/acrobat/kb/reader-core-dll-error.html

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Reader dos not respond after update installation

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