Reduce File Size - Other Options

I have a very large PDF file (521 mb) with about 6,500 b/w pages that I am trying to get to much smaller (under 350 mb). I am using Acrobat  Pro v9.2 and I have tried most of the typical file size reduction methods (Reduce File Size and different settings on Optimization). I have even tried to take the PDF and then "Save As a TIFF" file and then merge it back into a single PDF.
I have also to "Print to PDF" in an attempt to use the printer driver to recreate the PDF file but in a smaller size. Not much luck here either.
Now I was able to take a single page (2 mb) and "place" it into Photoshop and then "Print to PDF". This did create a nice resolution PDF file that was much much smaller (about 350 kb). This works, but it would take too long to do this with 6000+ pages so it really isn't a practical solution for a file with thousands of pages.
Does anybody have a technique or method to reduce a PDF with thousands of pages into a smaller overall size??? Or, d0 you know of optimization settings that I should use???
David

1) in the share dialog, you see some presets, mail, web, cd.rom.. choose one of these and your file size will shrink dramatically...
I personal prefer a "manual" setting, choose Quicktime, hit the button, and you get confronted with a second window, with zillions of options...
2) sure, spend some time reading..:
http://manuals.info.apple.com/en/iMovieLesson6.pdf

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