Reduced macbook pro performance, more spinning wheel

Greetings, my macbook pro has, in the last several weeks, begun running slower with an increased rate of the spinning wheel.  Below are the data from my etrecheck.  Any thoughts on what is causing the reduced performance?  Thank you!
EtreCheck version: 2.0.6 (91)
Report generated October 26, 2014 at 11:10:26 AM MDT
Hardware Information: ℹ️
  MacBook Pro (13-inch, Mid 2012) (Verified)
  MacBook Pro - model: MacBookPro9,2
  1 2.5 GHz Intel Core i5 CPU: 2-core
  8 GB RAM Upgradeable
  BANK 0/DIMM0
  4 GB DDR3 1600 MHz ok
  BANK 1/DIMM0
  4 GB DDR3 1600 MHz ok
  Bluetooth: Good - Handoff/Airdrop2 supported
  Wireless:  en1: 802.11 a/b/g/n
Video Information: ℹ️
  Intel HD Graphics 4000 -
  Color LCD 1280 x 800
System Software: ℹ️
  OS X 10.10 (14A389) - Uptime: 0:41:17
Disk Information: ℹ️
  APPLE HDD HTS545050A7E362 disk0 : (500.11 GB)
  S.M.A.R.T. Status: Verified
  EFI (disk0s1) <not mounted> : 210 MB
  Recovery HD (disk0s3) <not mounted>  [Recovery]: 650 MB
  Macintosh HD (disk1) /  [Startup]: 498.91 GB (326.94 GB free)
  Encrypted AES-XTS Unlocked
  Core Storage: disk0s2 499.25 GB Online
  MATSHITADVD-R   UJ-8A8 
USB Information: ℹ️
  Apple Inc. Apple Internal Keyboard / Trackpad
  Apple Inc. BRCM20702 Hub
  Apple Inc. Bluetooth USB Host Controller
  Apple Computer, Inc. IR Receiver
  Apple Inc. FaceTime HD Camera (Built-in)
Thunderbolt Information: ℹ️
  Apple Inc. thunderbolt_bus
Gatekeeper: ℹ️
  Mac App Store and identified developers
Launch Agents: ℹ️
  [not loaded] com.adobe.AAM.Updater-1.0.plist Support
  [loaded] com.oracle.java.Java-Updater.plist Support
Launch Daemons: ℹ️
  [loaded] com.adobe.fpsaud.plist Support
  [loaded] com.microsoft.office.licensing.helper.plist Support
  [loaded] com.oracle.java.Helper-Tool.plist Support
  [loaded] com.oracle.java.JavaUpdateHelper.plist Support
User Launch Agents: ℹ️
  [running] com.amazon.cloud-player.plist Support
  [loaded] com.google.keystone.agent.plist Support
User Login Items: ℹ️
  iTunesHelper Application (/Applications/iTunes.app/Contents/MacOS/iTunesHelper.app)
Internet Plug-ins: ℹ️
  FlashPlayer-10.6: Version: 15.0.0.189 - SDK 10.6 Support
  QuickTime Plugin: Version: 7.7.3
  Flash Player: Version: 15.0.0.189 - SDK 10.6 Support
  Default Browser: Version: 600 - SDK 10.10
  SharePointBrowserPlugin: Version: 14.4.4 - SDK 10.6 Support
  Silverlight: Version: 5.1.30514.0 - SDK 10.6 Support
  JavaAppletPlugin: Version: Java 8 Update 25 Check version
Safari Extensions: ℹ️
  Adblock Plus (Disabled)
  AdBlock
3rd Party Preference Panes: ℹ️
  Flash Player  Support
  Java  Support
Time Machine: ℹ️
  Time Machine not configured!
Top Processes by CPU: ℹ️
      7% mds
      4% WindowServer
      0% ocspd
      0% fontd
      0% AppleSpell
Top Processes by Memory: ℹ️
  352 MB Safari
  344 MB com.apple.WebKit.WebContent
  137 MB mds_stores
  69 MB WindowServer
  43 MB Spotlight
Virtual Memory Information: ℹ️
  4.33 GB Free RAM
  2.97 GB Active RAM
  442 MB Inactive RAM
  846 MB Wired RAM
  1.26 GB Page-ins
  0 B Page-outs

Greetings, my macbook pro has, in the last several weeks, begun running slower with an increased rate of the spinning wheel.  Below are the data from my etrecheck.  Any thoughts on what is causing the reduced performance?  Thank you!
EtreCheck version: 2.0.6 (91)
Report generated October 26, 2014 at 11:10:26 AM MDT
Hardware Information: ℹ️
  MacBook Pro (13-inch, Mid 2012) (Verified)
  MacBook Pro - model: MacBookPro9,2
  1 2.5 GHz Intel Core i5 CPU: 2-core
  8 GB RAM Upgradeable
  BANK 0/DIMM0
  4 GB DDR3 1600 MHz ok
  BANK 1/DIMM0
  4 GB DDR3 1600 MHz ok
  Bluetooth: Good - Handoff/Airdrop2 supported
  Wireless:  en1: 802.11 a/b/g/n
Video Information: ℹ️
  Intel HD Graphics 4000 -
  Color LCD 1280 x 800
System Software: ℹ️
  OS X 10.10 (14A389) - Uptime: 0:41:17
Disk Information: ℹ️
  APPLE HDD HTS545050A7E362 disk0 : (500.11 GB)
  S.M.A.R.T. Status: Verified
  EFI (disk0s1) <not mounted> : 210 MB
  Recovery HD (disk0s3) <not mounted>  [Recovery]: 650 MB
  Macintosh HD (disk1) /  [Startup]: 498.91 GB (326.94 GB free)
  Encrypted AES-XTS Unlocked
  Core Storage: disk0s2 499.25 GB Online
  MATSHITADVD-R   UJ-8A8 
USB Information: ℹ️
  Apple Inc. Apple Internal Keyboard / Trackpad
  Apple Inc. BRCM20702 Hub
  Apple Inc. Bluetooth USB Host Controller
  Apple Computer, Inc. IR Receiver
  Apple Inc. FaceTime HD Camera (Built-in)
Thunderbolt Information: ℹ️
  Apple Inc. thunderbolt_bus
Gatekeeper: ℹ️
  Mac App Store and identified developers
Launch Agents: ℹ️
  [not loaded] com.adobe.AAM.Updater-1.0.plist Support
  [loaded] com.oracle.java.Java-Updater.plist Support
Launch Daemons: ℹ️
  [loaded] com.adobe.fpsaud.plist Support
  [loaded] com.microsoft.office.licensing.helper.plist Support
  [loaded] com.oracle.java.Helper-Tool.plist Support
  [loaded] com.oracle.java.JavaUpdateHelper.plist Support
User Launch Agents: ℹ️
  [running] com.amazon.cloud-player.plist Support
  [loaded] com.google.keystone.agent.plist Support
User Login Items: ℹ️
  iTunesHelper Application (/Applications/iTunes.app/Contents/MacOS/iTunesHelper.app)
Internet Plug-ins: ℹ️
  FlashPlayer-10.6: Version: 15.0.0.189 - SDK 10.6 Support
  QuickTime Plugin: Version: 7.7.3
  Flash Player: Version: 15.0.0.189 - SDK 10.6 Support
  Default Browser: Version: 600 - SDK 10.10
  SharePointBrowserPlugin: Version: 14.4.4 - SDK 10.6 Support
  Silverlight: Version: 5.1.30514.0 - SDK 10.6 Support
  JavaAppletPlugin: Version: Java 8 Update 25 Check version
Safari Extensions: ℹ️
  Adblock Plus (Disabled)
  AdBlock
3rd Party Preference Panes: ℹ️
  Flash Player  Support
  Java  Support
Time Machine: ℹ️
  Time Machine not configured!
Top Processes by CPU: ℹ️
      7% mds
      4% WindowServer
      0% ocspd
      0% fontd
      0% AppleSpell
Top Processes by Memory: ℹ️
  352 MB Safari
  344 MB com.apple.WebKit.WebContent
  137 MB mds_stores
  69 MB WindowServer
  43 MB Spotlight
Virtual Memory Information: ℹ️
  4.33 GB Free RAM
  2.97 GB Active RAM
  442 MB Inactive RAM
  846 MB Wired RAM
  1.26 GB Page-ins
  0 B Page-outs

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    Hardware Information: ℹ️
        MacBook Pro (13-inch, Early 2011) (Technical Specifications)
        MacBook Pro - model: MacBookPro8,1
        1 2.3 GHz Intel Core i5 CPU: 2-core
        4 GB RAM Upgradeable
            BANK 0/DIMM0
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            BANK 1/DIMM0
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        Battery Health: Normal - Cycle count 646
    Video Information: ℹ️
        Intel HD Graphics 3000 - VRAM: 384 MB
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    System Software: ℹ️
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        [running]    com.trendmicro.itis.loginmgr.agent.plist [Click for support]
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        47 MB    softwareupdated
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        1.06 GB    Inactive RAM
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    I ran an EtreCheck on my laptop and this is what the report said. I've had this laptop for about 4 years and it just started freezing up around a week ago. The spinning wheel pops up every few minutes, slows down everything, and makes it extremely frustating to be using the laptop.

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    Apr 5 13:16:48 undevice [0x0-0x10010].com.google.Chrome[198]: Tue Apr 5 13:16:48 undevice.local Google Chrome Helper[209] <Error>: kCGErrorFailure: Set a breakpoint @ CGErrorBreakpoint() to catch errors as they are logged.
    Apr 5 13:17:20 undevice Goopy[165]: process it in Engine
    Apr 5 13:17:20 undevice Goopy[165]: process in EngineAdaptor
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    Apr 5 13:17:20 undevice Goopy[165]: start g composition
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    Apr 5 13:17:20 undevice Goopy[165]: generate compelete
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    Apr 5 13:27:45 undevice [0x0-0x10010].com.google.Chrome[198]: Wrote signal to shutdown pipe.
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      Macintosh HD (disk0s2) / [Startup]: 249.2 GB (97.28 GB free)
      Recovery HD (disk0s3) <not mounted>: 650 MB
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      Apple Inc. Apple Internal Keyboard / Trackpad
      Apple Computer, Inc. IR Receiver
      Apple Inc. BRCM2046 Hub
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      [loaded] com.adobe.fpsaud.plist Support
      [loaded] com.microsoft.office.licensing.helper.plist Support
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      [running] com.nike.nikeplusconnect.plist Support
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      FlashPlayer-10.6: Version: 13.0.0.214 - SDK 10.6 Support
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      497 MB Inactive RAM
      633 MB Wired RAM
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            Macintosh HD (disk0s2) / : 319.21 GB (145.89 GB free)
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        [running]    com.fitbit.galileod.plist [Click for support]
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        [loaded]    com.microsoft.office.licensing.helper.plist [Click for support]
        [running]    com.zeobit.MacKeeper.plugin.AntiTheft.daemon.plist [Click for support]
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        [loaded]    com.adobe.ARM.[...].plist [Click for support]
        [failed]    com.apple.CSConfigDotMacCert-[...]@me.com-SharedServices.Agent.plist
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        Fitbit Connect Menubar Helper    Application  (/Applications/Fitbit Connect.app/Contents/MacOS/Fitbit Connect Menubar Helper.app)
        Google Drive    Application  (/Applications/Google Drive.app)
    Internet Plug-ins: ℹ️
        DirectorShockwave: Version: 12.0.3r133 - SDK 10.6 [Click for support]
        o1dbrowserplugin: Version: 5.40.2.0 - SDK 10.8 [Click for support]
        Google Earth Web Plug-in: Version: 6.0 [Click for support]
        Default Browser: Version: 537 - SDK 10.9
        Unity Web Player: Version: UnityPlayer version 4.1.5f1 [Click for support]
        AdobePDFViewerNPAPI: Version: 11.0.10 - SDK 10.6 [Click for support]
        FlashPlayer-10.6: Version: 16.0.0.305 - SDK 10.6 [Click for support]
        Silverlight: Version: 5.1.20125.0 - SDK 10.6 [Click for support]
        Flash Player: Version: 16.0.0.305 - SDK 10.6 [Click for support]
        OnLiveGameClientDetector: Version: OnLiveGameClientDetector 1.0.0 [Click for support]
        googletalkbrowserplugin: Version: 5.40.2.0 - SDK 10.8 [Click for support]
        iPhotoPhotocast: Version: 7.0 - SDK 10.8
        AdobePDFViewer: Version: 11.0.10 - SDK 10.6 [Click for support]
        QuickTime Plugin: Version: 7.7.3
        SharePointBrowserPlugin: Version: 14.4.6 - SDK 10.6 [Click for support]
        JavaAppletPlugin: Version: 14.9.0 - SDK 10.7 Check version
    User internet Plug-ins: ℹ️
        WebEx64: Version: 1.0 - SDK 10.5 [Click for support]
        Picasa: Version: 1.0 - SDK 10.6 [Click for support]
        NPRoblox: Version: 1.0.2.12 - SDK 10.8 [Click for support]
        Google Earth Web Plug-in: Version: 6.2 [Click for support]
    Safari Extensions: ℹ️
        Pin It Button
    3rd Party Preference Panes: ℹ️
        AirServer  [Click for support]
        Flash Player  [Click for support]
        Perian  [Click for support]
    Time Machine: ℹ️
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        Auto backup: YES
        Volumes being backed up:
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        Destinations:
            FreeAgent Drive [Local]
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            Total number of backups: 3
            Oldest backup: 2014-11-03 17:43:59 +0000
            Last backup: 2015-01-29 01:15:07 +0000
            Size of backup disk: Too small
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            58%    MacKeeper
             8%    WindowServer
             1%    hidd
             1%    Fitbit Connect Menubar Helper
             1%    Notes
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        275 MB    MacKeeper
        120 MB    Mail
        82 MB    Safari
        64 MB    Messages
        64 MB    WindowServer
    Virtual Memory Information: ℹ️
        440 MB    Free RAM
        1.19 GB    Active RAM
        810 MB    Inactive RAM
        635 MB    Wired RAM
        6.82 GB    Page-ins
        1.83 GB    Page-outs

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