Reducing file size without loosing clarity

I have two designs for labels that have to be approved by the government for type size regulations.  The current size of the illustrator files are 133.3 MB and 24.7 MB I need to provide these at no larger than 450 kb AND the type must be readable and measurable for approval.
I have tried everything I can think of to provide the artwork small enough yet still retaining enough resolution to not make the type fuzzy and not able to be measured for size.  I've tried making the files from within illustrator, I've tried taking everything into Photoshop to make the JPEGS with no luck.  They want either a gif, jpeg or tiff no larger than 450 kb that is viewable at the print size of the label with no loss of resolution... Does anyone have any suggestions on how to create these?
Thanks in advance,
Nina

Photos, type gradients, complex paths, etc... and yes I know if they would just accept PDF files it would be no problem, but this is the Federal Government.  Do they ever do anything the easiest way.
I think I figured out a way to get these down in size without lossing too much... I took the background with all the complex paths and I made a separate JPEG put that back into an illustrator file, placed the type over it and made an RGB JPEG out of illustrator...used the type hinting and a low setting.  Got it down to 425 kb and well the type looks pretty darn good.  I hope this works because I've done this well over a dozen times and they've all been rejected.  This is the info the agency sent regarding it being rejected:
"Per Industry Circular 2011-4, your application and label(s) have not been reviewed for type size, characters per inch or contrasting background. The responsible industry member must continue to ensure that the mandatory information on the actual labels is displayed in the correct type size, number of characters per inch, and on a contrasting background in accordance with the TTB labeling regulations, 27 CFR parts 4, 5, 7, and 16, as applicable."
"One or more of your label images appear too small for the proper evaluation of your label(s). When the dimensions you specify are applied to the label, the system renders your label as a blurred image. Please remove the current image(s) and replace it with new, larger image(s). We advise that, when you develop your label images, the compression ratio should be set at MEDIUM or LOW so that the file is still within the file size limit of 450KB"
Thanks for your comment!

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