Reoccuring Message. Won't let anything other than Safari open.

Hello, 
On our Toshiba Satellite L305D computer, the message " Windows cannot access the specified device, path, or file. You may not have the appropriate permissions to access the item." This is weird considering it's showing up on the only profile that was ever used. 
Any help would be greatly appreciated, Thank You!

Which Satellite L305D? Which Windows?
What are you doing when the message appears?
Please attach a picture of the message.
-Jerry

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