"Required Files are Missing" ????

When I opened up iTunes yesterday morning, I was prompted to install the new version of iTunes. Did so, the install completed, and I turned off the computer because I had to go to work. This morning, I tried to open itunes and got the message: "iTunes cannot run because some of the required files are missing. Please re-install iTunes."
Does anyone know what this is about? I'm not thrilled with re-installing iTunes and building up my playlists all over again. What the heck happened??

Thanks, I'll give the repair a try tonight.
The couple of times I've tried to back up my iTunes it crashes about halfway through, so I don't have a backup. Really should work on that, you're right.
The last time I re-installed iTunes (was trying to update Quicktime following a computer crash, ended up re-installing both) it wiped out all my playlists and I had to start over.

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    Nodders:
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