Running Mail.app give spinning ball and freezes computer

My wife and I have different accounts on an iMac (2.33 GHz Intel Core 2 Duo) running 10.7.4. Her Mail.app has recently stopped working. When she launches Mail.app, the computer freezes and she sees the spinning ball. On my side of the computer, the Mail.app is still working. Any suggestions on how I can get her Mail program running again?
Thank you.

Donald and others:
This problem has been ongoing for about a week now. During that time, my wife has logged in and out of her account several times, and I’ve  rebooted the iMac several times. I've also run fsck, repaired disk permissions, and rebuilt the directory with Diskwarrior. But  Mail.app still isn't working.
I don’t know how it’s done nowadays, but there used to be plist files that stored preferences for particular apps. Every now and then one of those files would become corrupted,  and when that happened, the performance of the app would be negatively affected. At times,the problem could be solved simply by deleted the right preference files. I bring up this subject because, at lease in some crude sense, Mail.app is behaving as if it had a corrupted plist file.
Anyway, if someone would tell me what steps I should go through to attempt to solve this problem, I would appreciate it.
Thank you.

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