Runtime error with Adobe ReaderX

Hi..
Ever since I upgraded from XP to Vista SP2,
I have not been able to get Adobe reader to work.  Getting runtime error
"This application has requested the runtime to terminate it in an unusual way."  It does this whenever I try to open Adobe reader or a PDF on a web site.  Does any one have any idea what I'm doing wrong?

Did you do a clean upgrade to Vista or did you upgrade in place? Upgrading one version of Windows to another as opposed to doing a clean install can create problems.

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