Safari wont store preferences

Question

Suddenly in the last few weeks my Safari preferences won't stay. I set a home page and "a new window opens with the same page" and within a few minutes, Safari has forgotten it and when I open Safari I just get a blank page. I have tried deleting the com.apple.Safari.plist file which works temporarily, then it forgets everything again.
I am also having a problem with my monitors holding a calibration. I use a monitor test kit and the monitors aren't retaining the icc profile information. I mention this as it could be related??
I have a Mac Pro 3,1 with a quad-cor intel Xeon running Snow Leopard 10.6.8.
Any help or suggestions would be greatly appreciated!

Answer 1

Please read this whole message before doing anything.
This procedure is a test, not a solution. Don’t be disappointed when you find that nothing has changed after you complete it.
Step 1
The purpose of this step is to determine whether the problem is localized to your user account.
Enable guest logins and log in as Guest. For instructions, launch the System Preferences application, select Help from the menu bar, and enter “Set up a guest account” (without the quotes) in the search box.
While logged in as Guest, you won’t have access to any of your personal files or settings. Applications will behave as if you were running them for the first time. Don’t be alarmed by this; it’s normal. If you need any passwords or other personal data in order to complete the test, memorize, print, or write them down before you begin.
Test while logged in as Guest. Same problem(s)?
After testing, log out of the guest account and, in your own account, disable it if you wish. Any files you created in the guest account will be deleted automatically when you log out of it.
Note: If you’ve activated “Find My Mac” or FileVault in Mac OS X 10.7 or later, then you can’t enable the Guest account. Create a new account in which to test, and delete it, including its home folder, after testing.
Step 2
The purpose of this step is to determine whether the problem is caused by third-party system modifications that load automatically at startup or login.
Disconnect all wired peripherals except those needed for the test, and remove all aftermarket expansion cards. Boot in safe mode and log in to the account with the problem. The instructions provided by Apple are as follows:
Be sure your Mac is shut down.
Press the power button.
Immediately after you hear the startup tone, hold the Shift key. The Shift key should be held as soon as possible after the startup tone, but not before the tone.
Release the Shift key when you see the gray Apple icon and the progress indicator (looks like a spinning gear).
Safe mode is much slower to boot and run than normal, and some things won’t work at all, including wireless networking on certain Macs.
The login screen appears even if you usually log in automatically. You must know your login password in order to log in. If you’ve forgotten the password, you will need to reset it before you begin.
Note: If FileVault is enabled under Mac OS X 10.7 or later, you can’t boot in safe mode.
Test while in safe mode. Same problem(s)?
After testing, reboot as usual (i.e., not in safe mode) and verify that you still have the problem. Post the results of steps 1 and 2.