Satellite L300-1AP will not boot even in safe mode

After trying to boot in safe mode I get (after 10 minutes or so) the following.....
Windows failed to start. A recent hardware or software change might be the
cause. To fix the problem:
1. Insert your Window installation disk and restart your computer.
2. Choose your language settings, and then click "Next."
3. Click "Repair your computer."
If you do not have this disk, contact your system administrator or computer
manufacturer for assistance.
File: \Windows\system32\config\system
Status: 0xc00000e9
Info: Windows failed to load because the system registry file is
missing, or corrupt.
As the the OS was pre installed, no Windows disk is available. Have tried Windows repair, but get a similar message. Have tried F8 upon boot and have tried to restore to most recent working state but get the same as above. Is there any other way of repairing this or is this a hard disk issue? Help!

Thanks for your reply Horwath, unfortunately after about 15 minutes I get this instead:
Windows failed to start. A recent hardware or software change might be the
cause. To fix the problem:
1. Insert your Window installation disk and restart your computer.
2. Choose your language settings, and then click "Next."
3. Click "Repair your computer."
If you do not have this disk, contact your system administrator or computer
manufacturer for assistance.
Status: 0xc000000f
Info:The boot selection failed because a required device is inaccessible.
I can't even do a boot log to find out where it's falling over. Any thoughts?
null

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