SAVE AS reduces file size, but do I lose quality?

I've got a large textbook with 4-color graphics and the file sizes can get out of control. When I replaced a single page and then doing a SAVE AS and overwriting the original, the file size dramatically reduced. Then I did a test, and found it works on all files. I am NOT resampling, or downsizing or trying to optimize. I created the PDFs using the printer's PDF specs. But if I can do a simple SAVE AS and reduce the file size, I'd like to. I've search the internet and can't find an answer. Most links were about optimizing or trying to force the file size smaller by manipulating the content.
Thanks in advance.

I use Indesign CS6, generate using " Adobe Preset PDF" settings I created for this printer  Have used these settings for years  without a problem. Yes, I just open, SAVE AS, and then close. NO changes whatsoever.  I suspect it removes duplicate information, but can't be sure.

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