Saving issues: "The file may be read-only" error message

I do a lot of scanning to pdf and will often have to add a newly scanned page to an existing archived pdf then resave it.
I have a very consistent workflow and use two screens. The folders that contain the archived files are always on my second screen while I work on the main screen.
After I have inserted the newly scanned page into the existing pdf very often I get an error message that the file cannot be saved:
The file may be read-only, or another user may have it open. Please save the document with a different name or in a different folder.
I am the only user, none of files are read-only, and I am certain that the file I am resaving is not selected (I can see that on my second screen).
Sometimes if I just click on the second screen to another folder it'll let me resave, but other times I have to close Windows Explorer completely.
I like to avoid renaming files: it's important to that the original filename be retained.
This seems to be happening a lot more with Acrobat X Pro than it did with version 9. This is highly annoying.
Any known workarounds?
dg

The folders that contain the archived files are always on my second screen
If in Windows (a Mac user would have to speak to this for that environment) -
If Windows Explorer is "focused" on the file (i.e., file selected) or has "focus" on the file(s) parent folder/directory you will get the alert dialog.
Close Windows Explorer or place its focus elsewere.
Also, if the preview feature is used for files within a folder (or for files in nested sub-folder) you'll experience similar "speed humps" in the work flow path.
Was not always this way but OS updates (XP, Vista, etc.) appear to have given us some nifty new options that, coincidentally, pose some gotchas.
Be well...

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