Send Button Stops Functioning on Some Email

We are using Exchange 2010 in online mode with Outlook 2007 (I have a couple of Outlook 2013 users who are having this problem, too, though). We experience
an intermittent failure of the Send button. The email doesn't go to the Outbox - nothing happens when the Send button is pressed and appears to be disabled. We
use the workaround of creating a new email and pasting everything over. 
I have seen some chatter in the past about inline JPEG signatures (we have them, but this has happened without them) with HTML email (we are in HTML
mode, but changing to RTF and then back to HTML, which has been suggested as a solution previously doesn't work). This happens on emails with attachments, emails with no attachments, emails that were saved to drafts, brand new replies, forwarded email, new
email. I can't see a pattern.
I remember reading something in 2011 about there being an issue with the Exchange store that was supposed to be resolved in a roll-up. We're current with our roll-ups and patches. 
Is anyone else experiencing this issue? 

Hi JMackey,
Is there the same issue when sending emails via OWA?
If you use "Ctrl+Enter" shortcut to send the email when the issue occurred, how about the result?
Best regards,
Niko Cheng
TechNet Community Support

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