Server 2012 Datacenter - local IIS site opens locally but not from PCs on the domain

This is my first multi-server domain server install on an existing domain. I have a new Server 2012 installed on our domain. This server will host an intranet site, not public facing. I managed to install IIS and have a working ASP/.Net site. I can open
the site while on the server. However, the server denies access to the site from PCs on this domain. I tried changing the security options for the site directory but I can't find the issue.
The directory security objects allowed include:
MYSERVER\IIS_IUSRS
But, "MYSERVER" does not acknowledge the security object:
MYDOMAIN\IIS_IUSRS
What settings have I missed? The default site on port 80 is working locally and from the domain. My site is on port 8080 and is not located under the c:\inetpub folder, where the working default site is located.
Thanks in advance,
Kurt

Update:
I installed SQL Express 2012 and Management Studio 2012 locally on "MYSERVER". Again, I can attach to my instance of SQL locally from this server but using SSMS2012 from my PC on the domain, the SQL instance is not found. This must be related to
the above issue.

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