Service sapdp80 timed out when starting GUI

Clients of my company access our SAP server by VPN. One new client met a problem, they can access VPN, however, when they start SAP GUI, there comes an error"connection to host xx.xx.xx.xx, service sapdp80 request timed out", in its detail, "time: Fri...;component NI; Release 640; Version 37; Module nixxi_r.cpp;line 1070;Method NiPconnect;Return code 12;Counter 1".
And its so weird that all other clients are ok with both VPN connection and SAP GUI log on. I searched SAP note for this error but found no result, and I came here for your precious working experience. Has anyone met this error before?
Looking forward to your help.

Yes it's the connecting problem. Are you able to phisicaly see the client PC , and check the VPN and TCP\IP settings? May be it's some firewall or antivirus software are installed on clients side. You need to analyse all, for example after VPN connection are established the "ipconfig /all" should show parameters with which user has got in your network to. Regards.

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