Skype audio through external interface

I'm currently running sound through an external audio interface (M-Audio Profire 2626). Before, everything was fine, but at the moment, Skype seems to be sending signal only to the left channel of the interface. All chat sounds, rings, and alerts are audible in the left channel only, but in a call, the other party comes through both speakers. So it's only alerts in the one speaker.
What's happening here?

When it was working, what was different?  Was there a specific version of Skype that it was more compatible with?  Since it doesn't occur on other devices (as far as I'm able to test since I own no Firewire output devices) I can only assume the issue is driver/software related or a compatiblity issue over Firewire but I would really suspect translation software that's being used to get it work in Skype unless the drivers are native WDM-based (vs something like ASIO).  If you have other firewire ports you've never used you can always try those to see if the install of that device on that specific port changes anything. 

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