Skype no longer working on my pc

I have been away for several weeks with PC switched off and when I returned Skype was no longer working on my PC.  I still had the Skype icon on my desk top but all I get is " Windows can't find C:\Program Files (x86)\Skype\Phone\Skype.exe."
I have downloaded it again and followed all the installation steps but I still just get the Skype icon and the same message.  Skype was working fine before I went away.  I have never had problems with downloading Skype before. Any suggestions?

Most likely this is your case too (TuneUp "miracle" tool):
http://community.skype.com/t5/Windows-desktop-clie​nt/Skype-doesn-t-work-on-Windows-Started-at-Asus-...

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