Slow laptop that I just can't seem to fix - Mingler issue?

So my laptop has been intermittently slowing to a crawl. It seems from viewing Activity Monitor that the culprit is Mingler which is related to syncing. At it's worst the machine is unusable taking 10-20 seconds or more to respond to a mouse click and pinwheeling endlessly. I've also been getting this message:
"Your mac os x startup disk has no more space for application memory. To avoid problems with your computer, quit any applications you are not using. Closing windows and removing files from your startup disk will also help"
Which is sorta crazy: I have 8GB of ram and I have two internal 500GB hd's striped in a 0 raid for 1TB of internal of which 650GB is available. The only programs running when I get this are: Mail, Safari, Finder and Activity Monitor.
Mingler is using anywhere from 5.47 to the full 8GB of Real Mem and 60GB or more of Virtual Memory. It's often taking 95-98% of memory.
Outside of Mingler I am running out of ideas for the machine being so slow. I've defraged the disk with idefrag, I've rebuilt the permissions with both Disk Utility and Disk Warrior and I've run Disk Warrior on the disk. I was getting SUID errors that were reporting damaged files that were not repaired. Finally I reinstalled the OS but it made no difference.
This machine is essential to my work and it's letting me down. Last week during a Keynote presentation it was taking 20-30 seconds to switch slides front of an audience of almost 200 people. I had to have the tech person run the presentation from my backup on their laptop. Next week I have a location job in Colorado where I have to shoot tethered to this machine. I need to figure this out.
I'm now scaling the size of the drive back in preparation of installing two SSD drives in a striped Raid to get the machine as fast as possible but I don't want to install a damaged system onto new drives. I don't want to have to do a clean install and suffer having to reinstall all my programs. That can't be the only option - can it?
What can I do to get my fast machine back? Help!
G

What happens if you get rid of Mingler given what you've described? I've never seen a process called Mingler, but you may find help in this discussion.

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