Sluggish iMac performance; maintenance help needed

I have a 21.5 inch, mid-2011 iMac with 12 GB memory and a 1 Tb drive (660 GB free). Have upgraded to Mavericks, and the iMac is running slow (although it was sluggish prior to the upgrade).
Am looking for advice on how to get things sped up a bit. I have removed some unneeded startup items. And have run EtreCheck with results as follows. Have also repaired permissions and verifed disk. All seems to be in order.
Can anyone offer additional hints on performance improvments before I go with a clean install?
Hardware Information:
          iMac (21.5-inch, Mid 2011)
          iMac - model: iMac12,1
          1 2.7 GHz Intel Core i5 CPU: 4 cores
          12 GB RAM
Video Information:
          AMD Radeon HD 6770M - VRAM: 512 MB
Audio Plug-ins:
          BluetoothAudioPlugIn: Version: 1.0
          AirPlay: Version: 1.9
          AppleAVBAudio: Version: 2.0.0
          iSightAudio: Version: 7.7.3
System Software:
          OS X 10.9 (13A603) - Uptime: 0 days 3:34:26
Disk Information:
          WDC WD1001FALS-403AA0 disk0 : (1 TB)
                    EFI (disk0s1) <not mounted>: 209.7 MB
                    Macintosh HD (disk0s2) /: 999.35 GB (661.02 GB free)
                    Recovery HD (disk0s3) <not mounted>: 650 MB
          OPTIARC DVD RW AD-5690H 
USB Information:
          Dynastream Innovations ANT USBStick2
          Apple Computer, Inc. IR Receiver
          Apple Internal Memory Card Reader
          Apple Inc. FaceTime HD Camera (Built-in)
          Tripp Lite  Tripp Lite UPS 
          Apple, Inc. Keyboard Hub
                    Apple, Inc Apple Keyboard
          Apple Inc. BRCM2046 Hub
                    Apple Inc. Bluetooth USB Host Controller
FireWire Information:
Thunderbolt Information:
          Apple Inc. thunderbolt_bus
Kernel Extensions:
Problem System Launch Daemons:
Problem System Launch Agents:
Launch Daemons:
          [loaded] com.adobe.fpsaud.plist
          [loaded] com.bombich.ccc.plist
          [loaded] com.Cvnt.Uninstall.plist
          [loaded] com.microsoft.office.licensing.helper.plist
Launch Agents:
          [loaded] com.epson.eventmanager.agent.plist
User Launch Agents:
          [loaded] com.adobe.ARM.[...].plist
          [loaded] com.adobe.ARM.[...].plist
          [failed] com.apple.MobileMeSyncClientAgent.plist
          [loaded] com.google.keystone.agent.plist
User Login Items:
          AirPort Base Station Agent
          ZSyncDaemon
          Dropbox
3rd Party Preference Panes:
          Flash Player
          MacFUSE
Internet Plug-ins:
          AdobePDFViewer.plugin
          AdobePDFViewerNPAPI.plugin
          Default Browser.plugin
          DivXBrowserPlugin.plugin
          Flash Player.plugin
          FlashPlayer-10.6.plugin
          Flip4Mac WMV Plugin.plugin
          GarminGpsControl.plugin
          Google Earth Web Plug-in.plugin
          iPhotoPhotocast.plugin
          OfficeLiveBrowserPlugin.plugin
          Photo Center Plugin.plugin
          QuickTime Plugin.plugin
          SharePointBrowserPlugin.plugin
          Silverlight.plugin
User Internet Plug-ins:
          CitrixOnlineWebDeploymentPlugin.plugin
          WebEx.plugin
Bad Fonts:
          None
Time Machine:
          Skip System Files: NO
          Mobile backups: OFF
          Auto backup: NO
          Volumes being backed up:
                    Macintosh HD: Disk size: 999.35 GB Disk used: 338.32 GB
          Destinations:
                    Data [Network] (Last used)
                    Total size: 497.96 GB
                    Total number of backups: 45
                    Oldest backup: 2013-03-30 05:21:00 +0000
                    Last backup: 2013-06-20 14:28:08 +0000
                    Size of backup disk: Too small
                              Backup size 497.96 GB < (Disk used 338.32 GB X 3)
Top Processes by CPU:
               1%          WindowServer
               1%          EtreCheck
               1%          PluginProcess
               0%          fontd
               0%          EEventManager
               0%          Dropbox
               0%          com.apple.WebKit.Networking
               0%          dpd
Top Processes by Memory:
          2.36 GB            Safari
          418 MB             mds_stores
          307 MB             com.apple.WebKit.WebContent
          172 MB             com.apple.appkit.xpc.openAndSavePanelService
          147 MB             com.apple.IconServicesAgent
          135 MB             softwareupdated
          98 MB              Mail
          74 MB              Dropbox
          61 MB              PluginProcess
          61 MB              WindowServer
Virtual Memory Statistics:
          3.06 GB            Free RAM
          5.53 GB            Active RAM
          2.14 GB            Inactive RAM
          1.27 GB            Wired RAM
          470 MB             Page-ins
          0 B                Page-outs

I don't see anything obvious that would be causing your Mac slowdowns.
You need to update all of your third party software if there are OS X Mavericks updates that can be applied. You may need to go the third party developers' websites if there are no updates through the Mac App Store.
Update all of your Web browser Internet plugins, also.
Also, if you have any third party devices, like keyboards, mice, drawing tablets, hubs, card  readers, etc, you need to update the drivers for these devices to OS X Mavericks compatible versions.
Good Luck!

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