Sluggish timeline and glitching/freezing program monitor in Premiere Pro CC 8.1

Question

Hi all,
I've recently switched from CS6 to the 2014 Adobe CC due to a student license expiring. I'm also somewhat new to r3d workflow so chances are I may be doing something wrong.
I've worked on one other project with a mix of r3d and DSLR footage in CS6, but this is my first time cutting with red footage in Premiere CC.
*Apologies in advance for the novel, but I figured I'd be as thorough as possible to hopefully help get this issue resolved for myself any anyone else who's experiencing this.*
I'm cutting a 9:30 "party mix" in a music video style edit. So far I've had several (seemingly random) issues and glitches, that have been making my life exceptionally difficult and this 10/30 deadline exceptionally scary.
I'm working with content that we captured using exclusively RED Epic Dragon, and Epic Mysterium cameras. We recorded with several different frame rates, with varying resolution, compression, and aspect ratios. Project was set in-camera to 23.976.
Issue #1
I've created a nearly two hour, organized roll of sub-clip selects in a RED R3D 2K 23.976 16x9 timeline, in which i'll use to browse my raw media when sequencing on a timeline stacked directly below.
Often times when pulling clips from one timeline down to the other, the over-all responsiveness of the program will become ultra sluggish. Causing a clip (that's being dragged/placed) to lag heavily, maybe a couple seconds behind my cursor. This issue will often resolve itself after maybe 5 minutes or so, but makes fluid sequencing rather difficult.
Issue #2
The other issue I'm having is a glitchy or completely unresponsive program monitor. Again this issue appears to be totally random, and seems to happen most when I'm deep into some really intense sequencing/ clip arrangement, and scrubbing quickly.
Usually a portion of a single clip (or sometimes a couple clips) will freeze up in the program monitor while I'm scrubbing over them on the timeline. This will sometimes cause them to freeze all together during playback as well as cause surrounding clips to lag a bit (maybe 4-8fps).
I'll scrub back over the problem area and sometimes get a solid green bar halfway through my image, usually right before the program monitor just reads solid black throughout the entire timeline. This issue is temporarily resolved by restarting the program (about every 15-30 minutes).
Issue #3
As I'm scrubbing I'll also experience heavy glitching with both my image and the program monitor GUI itself. However, this issue typically wont affect playback.
I've uploaded a quick camera-phone video of this issue as it's a little tough to describe Program monitor glitch - YouTube
I know the timeline is un-rendered in this sample, (but this issue happens either way).
Two painstaking weeks later, I've finally completed the first pass.
Working on revisions now, and ultimately I'd like to copy paste the sequence into a 4K timeline for before After Effects work and export.
I tried pulling it into a 4K timeline (with playback set to 1/8 res) and the issues stated above got 10x worse.
Sticking to the 2K timeline for now (with playback at 1/4 res)
P.S. I'm also cutting a much simpler corporate project with 5DMKIII footage and having no real issues.
As for my rig,
I'm running Adobe Premiere CC 2014 v8.1
Freshly installed Windows 7 Professional SP1 PC Desktop
Freshly installed Samsung 1TB SSD running my OS and Adobe CC
Intel Core i7-2600k CPU at 3.4GHz (8CPUs) - Watercooled
16GB Ram (3gb allocated for other programs)
Nvidia GeForce GTX 570 4GB GDDR5 - 3.40.62 Drivers installed
Pulling media from 2x 3TB Seagate Barracuda 7200RPM drives, striped at RAID 0
Thanks for reading!
-Sam

Answer 1

So it seems to be behaving slightly better in "Software Only"
Though slightly less frequently, I'm still running into the issues stated above, mostly issue #2.
I also have a new problem to add to this thread as I'm starting to pull clips into After Effects.
First being that (again, seemingly random) dynamic-linked clips decide not to show up on the timeline in AE, and then seem to vanish from the program monitor in Premiere as well.
As you can see in the screenshots attached- After Effects see's the media itself from which the clip came from, however it won't show up in the monitor.
I'm also having issues where I'll render the Premiere project with the dynamic linked clips that DO work, and then as soon as I restart the program, those previews are gone and I have to re-render the the AE Linked comps.