Smtp failed connection attemp

Hi
This is my scenario
Exchange 2010 --> TMG 2010--> UBM Xroads --> ISP
My TMG runs on Hyper-V and Windows 2008 R2 hosted for Windows server 2012 R2
two NICS
When i publish the Exchange server on TMG receive without problems but send email is not working
Failed Connection Attempt PMSNTMGSVRV 25/02/2014 10:01:38 a.m.
Log type: Firewall service
Status: A connection attempt failed because the connected party did not properly respond after a period of time, or established connection failed because connected host has failed to respond. 
Rule: mailOUT
Source: Internal (192.168.1.20:7419)
Destination: External (85.158.140.211:587)
Protocol: mail
 Additional information
Number of bytes sent: 0 Number of bytes received: 0
Processing time: 21015ms Original Client IP: 192.168.1.20
I´m already chek NIC config and all seems to be ok. but i´m stuck with this.
Any idea?

Hi, check if the destination Server is listening on port 587. SMTP traffc normally uses TCP port 25
regards Marc Grote aka Jens Baier - www.it-training-grote.de - www.forefront-tmg.de - www.galileocomputing.de/3570

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