Solutions for 3TB USB 3 Seagate hdd becomming unresponsive after sustained (about an hour) usage on iMac7,1 running Lion 10.7.1?

I am running Lion 10.7.1 on my iMac7,1. After Time Machine warned that my 2TB Western Digital MyBook drive had filled up, I purchased a Seagate 3TB FreeAgent Desk USB 3 hdd for use with Time Machine with the understanding that USB 3 is USB 2 backward compatible. About an hour after initiating my Time Machine backup, I have repeatedly observed that the drive becomes non-responsive, causing finder, or any other program trying to access it to get stuck at a spinning beach ball. After repeatedly reformatting the drive, and repeating the process, I contacted Seagate tech support that informed me that there were seeing many cases of problems with USB 3 devices not working properly (in USB 2 compatibility mode) with Macs. Has anyone else seen this type of behaviour that can suggest a fix?
Relevant details:
I'm using a 24" iMac7,1 with 6 GB of RAM and a 2TB internal WD hard drive running Mac OS X Lion 10.7.1.
I have been using Time Machine in Leopard, Snow Leopard, and Lion with a 2TB USB 2 WD MyBook external hdd with no appearant issues.
I am having issues with a Seagate STAC3000101 drive that consists of 2 reassembled modules.
a appearantly stock SATA drive in a self-contained plastic housing with a bit extra sheilding and mechanical reinforcement on the SATA connector.
a USB 3.0 base that takes external power, and connects to the above module.
The drive was formatted with a single 3 TB Mac OS X Extended (Case-Sensitive/Journaled) partition formatted by Mac Disk Utility
Testing has revealed that
Copying a > 4GB file to the drive does not cause the problem (This sounded like a Windows 32 bit filesystem issue anyway)
Causing Lion to "Sleep" while in the middle of a file copy did not cause the problem either. (Waking the system made it pick up right where it left off).

I don't recommend using any sort of 'disk cleaning' software - OS X is based on Unix and cleans up after itself very well: no need to use utilities that purport to 'clean' your system and certainly not on a daily basis. If you must use anything I would recommend use Onyx - and just using it to clear logs and caches maybe a couple of times a year.
I'm not suggesting that Ccleaner had/has anything to do with your problem. It could even be out-of-date Wacom tablet drivers.
As for the Unarchiver software, the Mac has zip unarchiving built in and I would suggest using one of the unrar apps available in the App Store if you run into rar files for some reason. Again, it's likely not at the root of your problems, but there are free or nearly free alternatives.
Have you tried upgrading to Mountain Lion, particularly on your 2012 machine? It's supposed to fix some USB problems. Also make certain again that you have the very latest Wacom drivers - that's really the only thing that I can see that might be causing the problem on both of your machines.
Good luck,
Clinton

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