Some app use only channel 1 and 2 of a 6 channel sound card

Hi,
I use a Native Instruments Audio 6 soundcard, that has 6 channels. In Mac's Audio Midi Setup speaker configuration I configured that channel 5 and 6 have to be used for stereo. This works for quite a lot of apps, like Safari and iTunes, but other apps, like Chrome and XBMC, route their audio through channel 1 & 2. How can this be solved?
This issue in the link below I had earlier, which I have fixed. It could be related, but it is not the same.
http://forums.presonus.com/posts/list/30/27007.page
Thanks,
Robert

Start with uninstalling and re-installing the driver.

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