Some applications are not opening

Hi,
Many of my applications are not opening. Sometimes when I try to open the application it doesn't even bounce in the dock.  Other times, applications will bounce in the dock and then stop.  These are crucial apps, like Mail, Pages, and iPhoto.  Safari and iTunes are working fine.
Here is some information on my mac:
I have an early 2008 MacBook Pro, 2.5 Ghz Intel Core 2 Duo, 250 GB HDD, and 4 GM DDR2 Crucial RAM. I am running the latest versions of Snow Leopard, iWork, and iLife. So my computer is up to date (software wise).
Does anyone know what could be going on with my computer?
I have already tried repairing the disk and repairing the disk permissions in disk utility through the OS as well as the install disc.  Is there anything else I should try doing before taking my computer into the Apple store?
Thanks,
Max

That didn't work =/
I'm still having the same issues even with a new account.

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