"Some files that need to be updadted are currently in use."

I have Windows Vista, and iTunes has not been working on my computer for a few months now. I was hoping this new version (7.4 the latest one) would finally be able to run. Unfortunately, when I run the installer, I get a window that says this:
"Some files that need to be updated are currently in use."
"The following applications are using files that need to be updated by the installer. Close these applications and click Retry to continue"
"Windows Explorer (Process ID: 2440)"
How should I deal with this? And what if I still get the "iTunes has stopped working" message if I do manage to install it? Thanks for trying to help!

Sorry to bump up an old thred.
I too ran into the same error. It was the vagueness of the error message which surprised me.
What I used Unlocker [http://ccollomb.free.fr/unlocker/] on the folder "C:\Program Files\Adobe\Reader 9.0", it showed some 6 to 7 files in use by the Windows Search Indexer.
I unlocked all the files and was able to update Adobe Reader.

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