Some kind of corruption introduces massive latency

Hi Gentlemen.
Has anyone else come across this problem.
When I open this particular tune ( One I have to mix sharpish)
Regardless of the buffer setting I get a 40 or 50 msec delay.
Opening a new song exhibits no latency.
If anyone has come across this problem and solved it I'd appreciate their advice

Well, thanks for all the help guys!!!
Actually I sorted it out.
I had latency compensation set to "all". Which I foolishly expected to apply Latency compensation to, well,... All.
Naturally it doesn't. Christ knows what it does. I really must read a manual one day

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