Songs are being transferred to iPod in a corrupted manner, please help

We have two iPods in the family, and both are suffering from the same problem with the same songs.
One of the iPods I have had for about three years with no problems.
On many transferred songs, the iPod stops a song in the middle of play and skips to the next song in the playlist lineup. This happens with the same songs on both iPods.
So far, it's only happening on songs that I transferred from CDs. However, these are not newly transferred songs, these are songs that have been in my library for years.
The problem occurred after I recently updated my iTunes to the most current version. To my surprise, iTunes rebuilt the library on my iPods after updating with the new version software.
It is after this re-write that the problems started. I also, around the same time, relocated all of my music files to a different hard drive with greater storage capacity, so I am not sure if this manual moving of files caused any problems.
Thus far, none of my purchased music from iTunes has been impacted.
When I play the songs on my PC from within iTunes, I have no problems. It's only when play on the iPods.
Has anyone else experienced this?
How can I completely reformat my iPods to try and re-write.
Any remedies that I might look at?

I'm having the exact same problems. Many songs sound like utter crap (lots of popping and crackling where there was none previously), and more than a dozen songs are prematurely ending (about 10 seconds prior to the actual end of the song). When I check the play times of the songs on the iPod versus the times my iMac has in iTunes, they're about 8-12 secs off. I've even deleted the songs from both the iPod and iTunes, re-ripped the CDs but the same issues applies. I've also tried cleaning out the iPod completely with iPod Updater.
I hope someone else can validate what MrAceXPS have come across.
iMac G5 1.6 GHz, 1GB Corsair, 160GB   Mac OS X (10.4.4)   2nd Generation iPod 10GB (purchased 12/2003)

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