Speakers no longer working on Mac- weird symbol won't let me change volume

Hello
First off, I am not super computer savy!
My mac's internal speakers are no longer working. The volume control has faded in color, and when I try to press the volume buttons on the keyboard, it won't let me change the volume and there is a weird circle with a line through it. When I reboot the computer makes the reboot sound. I have tried tinkering around with the system preferences, but it is not muted, and it won't let me adjust the volume at all. This happened once before, the other day. Came out of nowhere and started working after about 10 minutes. Any suggestions! Much appreciated
Kate

Hi,
What output do you receive if you enter this command in the Terminal (Applications -> Utilities -> Terminal.app):
<pre>codesign -vvv Safari.app</pre>
If Safari has been modified, such as by a Safari enhancer program, this command should inform you.
If that is the case, try reinstalling the Safari package from the 10.5 installer DVD. This article relates to reinstalling Safari from the 10.4 DVD, but the principle is the same.

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