Sync freezes my laptop

Hi
I have the following set up: IPod touch 32GB, Vista Business OS and a new Vaio BX61MN. When I go to sync my touch with ITunes after transferring around 50 songs from my 3,000 library across to the touch......it freezes.
Laptop becomes totally frozen and after 30 mins this message comes up +"IPoint.exe has stopped working"+ I also get a separate box which says +"The iTunes library file cannot be saved. An unknown error occurred (-1450)"+
What I believe is happening here is that iTunes has problems accessing data off the SATA hard drive and so is freezing.
This is what I have been doing:
1) Turn on laptop.
2) Connect iPod touch to laptop to open ITunes.
3) IPod and iTunes automatically begin to sync.
4) 3,000ish songs start to sync, after 40 to 120 songs sync copy across to my ipod touch the laptop freezes up.
At this time I cannot shut iTunes’s down or open up any other programme. The whole thing sits there like a lemon for ages, 30 mins plus. I have recently discovered that if I unplug the iPod (which I hate to do unless by the correct methods) then the laptop gets back some functionality but it runs as if 25megs of ram were installed, runs like a pig until I reboot which can take 30 mins to 3 hours in one case.
If I switch sync off then I can drag the entire library into my touch with no problems, it all transfers across but after that when I switch sync back on.......it freezes again even though it is not now moving songs onto my iPod.
Any help would be great.

Try:
iTunes for Windows Vista or Windows 7: Troubleshooting unexpected quits, freezes, or launch issues
(it includes a link for XP)
iOS: Troubleshooting backup issues in iTunes

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