System preference pane is too slow to use.

As stated, my preferences>appearance window show spinning wheel for a very long time (15+sec) every time I make a selection.
If I log in as a different user it works normally.
I've zapped parameter ram
I've reset-nvram and reset-all from open firmware
I've trashed my .....systempreferences.plist file
Restarted computer.
Nothing helps.
Any ideas? Thanks

Bonnie,
Start *Windows'* safe mode with networking enabled
- win8 http://windows.microsoft.com/en-us/windows-8/windows-startup-settings-safe-mode
Still In Windows safe mode, start thunderbird in safe mode
- http://support.mozillamessaging.com/en-US/kb/safe-mode
Does problem go away?
And, what antivirus software do you use?

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