System preferences can't be opened 600

Latest update of lion and all updates done.. gettint the error message when trying to open .. the Application System Preferences can't be opened. -600..
Any suggestions...
Linda

Thank you for your quick and helpful response.. I repaired permissions before I received your advice and that seemed to solve the problem ..BUT.. I'm not convinced that it won't return.. My entire machine has. Not been behaving since the update....
L

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