'System Preferences' gets hanged. Not able to change any settings.

I'm not able to change my wallpaper. Main issue is as soon as I open 'System Preferences', the window opens but I'm not able to click on anything. Not able to change any settings. Tried restarting but no help.
Please help.

Please read this whole message before doing anything.
This procedure is a diagnostic test. It’s unlikely to solve your problem. Don’t be disappointed when you find that nothing has changed after you complete it.
The purpose of this exercise is to determine whether the problem is caused by third-party system modifications that load automatically at startup or login. Boot in safe mode and log in to the account with the problem. First, disconnect all wired peripherals except keyboard, mouse, and monitor, if applicable, and remove all aftermarket expansion cards. The instructions provided by Apple are as follows:
Be sure your Mac is shut down.
Press the power button.
Immediately after you hear the startup tone, hold the Shift key. The Shift key should be held as soon as possible after the startup tone, but not before the tone.
Release the Shift key when you see the gray Apple icon and the progress indicator (looks like a spinning gear).
The login screen appears even if you usually log in automatically. You must know your login password in order to log in. If you’ve forgotten the password, you will need to reset it before you begin.
Safe mode is much slower to boot and run than normal, and some things won’t work at all, including your login items.
Launch the application(s) and test. Same problem(s)?
After testing, reboot as usual (i.e., not in safe mode.)

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