System Prefs - options greyed out or non-functional

I have been having a bad time lately with my System Prefs. I first noticed it when settings to Mouse and Sound would not retain after a restart.
Now the problems are much worse...
I cannot open the Date & Time pane at all (ignores clicking), all options in Sharing are grayed out and cannot be changed (even though account is admin and the lock is unlocked), I am unable to create a new user, and changes to Energy Saver result in spinning color wheel.
I have deleted every preference and cache I could find in the user and rebuilt permissions but no luck. I am considering enabling root and seeing if that can go in and make changes since I cannot create a new admin user otherwise.
Short of a painful OS reinstall anybody have suggestions?
I also might consider riding it out and waiting for 10.5.

Ralph Johns (UK) (to Emily Vu) 19 minutes ago
Hi,
Check the Font AppleGothic.ttf is active and validates using the Font Book app.
if you have to change anything restart the Mac.
If this is not the issue go to ~/Library/Preferences and find com.apple.ichat.plist and Drag it to the Trash and then restart Messages.
The above reply in another thread solved my issue! Namely that my apple gothic font was disabled, breaking the entire Messages app.

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