TB "not responding" most of the time.

Windows 8, i-7 16 GB RAM. McAfee fixed settings but same problem. No difference in Safe Mode. I deleted the global data and tried all other TB site recommendations but still no change. I do have a fair amount of emails in archives. Not sure if this makes a difference.
Please help.

The first port of call is windows safe mode with networking. Not only does this disable McAfee it also disables a range of other tools and products and leaves you with basically just Thunderbird running. If there is no improvement in that mode, restart Thunderbird with add-ons disabled from the help menu. Now you have windows pared down to almost nothing and Thunderbird in a similar situation. Hopefully at that point normal Thunderbird activity should surface. Suggestions as to cause really depend on your results.
Thunderbird safe mode it almost always an add-on but it is a case of identifying it through repeated enabling and disabling of add-ons. At one stage Lightning was causing slowness. There is a security key technology used by the US military that must be reinstalled after Thunderbird or Thunderbird crashes.

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== This happened ==
Every time Firefox opened
== weeks ago

It's possible that you are having a problem with some Firefox add-on that is hindering your Firefox's normal behavior. Have you tried disabling all add-ons (just to check), to see if Firefox goes back to normal?
Whenever you have a problem with Firefox, whatever it is, you should make sure it's not caused by one (or more than one) of your installed add-ons, be it an extension, a theme or a plugin. To do that easily and cleanly, run Firefox in [http://support.mozilla.com/en-US/kb/Safe+Mode safe mode] (don't forget to select ''Disable all add-ons'' when you start safe mode). If the problem disappears, you know it's from an add-on. Disable them all in normal mode, and enable them one at a time until you find the source of the problem. See [http://support.mozilla.com/en-US/kb/Troubleshooting+extensions+and+themes this article] for information about troubleshooting extensions and themes and [https://support.mozilla.com/en-US/kb/Troubleshooting+plugins this one] for plugins.
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My home button does not respond most of the time. Is this a hardware failure?

I've had quite a bit of difficulty with getting my home button to respond. Sometimes, the only way to get back to the home screen is to do a hard reset. I constantly close any open apps, thinking that this might be the problem (memory issue).
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http://appletoolbox.com/2010/04/ipad-wi-fi-problems-comprehensive-list-of-fixes/
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~~~~~~~~~~~~~~~
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TB "not responding" most of the time.

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