The application cannot be launched -10810

I just started getting the following error message on my iMac Core Duo:
The application "Firefox, Address Book, System Preferences --insert app name here" cannot be launched -10810
This seems to happen after the Mac has been running for a while (a day or so), and restarting it seems to fix the problem. But, it's annoying that it continues to happen. When it does, I can use the programs that are already open, but I cannot launch any new programs. Many other functions, such as simply double clicking a printer to open its dialog box, just don't do anything.
I've had other problems with the Mac freezing up and needing to hold down the power button for several seconds to restart it. I don't know if it's related. I've had the Mac sicne not long after the Intel models were released, is it possible that over the last several months I've gotten some non Rosetta/non Intel friendly software that's causing problems?
Thanks,
iMac Core Duo 20"   Mac OS X (10.4.6)   Intel, 256MB Video Card, 1.5GB Ram
iMac Core Duo 20"   Mac OS X (10.4.6)  

That error message means that you have too many applications and processes open on the iMac. Turning off Windows File Sharing from the Sharing pane of System Preferences except when you need it turned on will help. Otherwise, the next time you restart, open the Activity Monitor in the /Applications/Utilities/ folder immediately and keep an eye on what it reports while you work.
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